B-MODE ULTRASOUND-GUIDED LOW-LEVEL FOCUSED-ULTRASOUND SONODYNAMIC THERAPY OF NEOINTIMAL HYPERPLASIA USING PHOTOFRIN-LOADED MICROBUBBLES

BackgroundIn vascular surgery, neointimal hyperplasia is a significant clinical phenomenon because it reduces the long-term effectiveness of surgical and endovascular procedures. We devised an experimental sonodynamic therapy protocol tested its efficacy on reduction in this study, which diagnostic B-mode ultrasound paired with focused-ultrasound goal greater safety.Methods ResultsGolden Syrian hamsters were subjected to endothelial denaturation damage by abdominal aorta ballooning (approximately 0.5 cm superior iliac bifurcation). Histopathology results after eight weeks revealed increased smooth muscle cell proliferation intimal layer, culminating vessel wall thickening. The treatment group, then received pulsed-low-level (F= 1.1 MHz, P= 15 W, PD= 250 ms) sonosensitizer photofrin-loaded PESDA (Perflurocarbon Exposed Sonicated Dextrose Albumin) microbubbles (100ml/kg, 2-5 105 bubbles/ml). development inertial cavitation was imaging combined therapy. In addition, when comparing group other groups, histopathological substantial mean value for density, lumen thickness, percentage luminal cross-sectional area stenosis (p < 0.05).ConclusionEnhanced cytoxic effect photofrin, induced low-level enhanced sonoporation focused ultrasound, collapsed bubbles, can cause layer thickness be reduced significantly dilated. safety. Methods 0.05). Golden ConclusionEnhanced Enhanced